IODIDE ORGANIFICATION DEFECT IN A COLD THYROID NODULE: ABSENCE OF IODIDE EFFECT ON CYCLIC AMP ACCUMULATION |
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| Authors: | N. DEMEESTER-MIRKINE J. VAN SANDE P. DOR R. HEIMANN P. COCHAUX J. E. DUMONT |
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| Affiliation: | Department of Medicine, Brugmann University Hospital, Institute of Interdisciplinary Research, School of Medicine, Department of Surgery and Department of Pathology, Institut Bordet, School of Medicine, University of Brussels, Brussels, Belgium |
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| Abstract: | A follicular adenoma of the thyroid was 'hot' one hour after 99mTc pertechnetate administration, but 'cold'24 h after 131I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH-induced cyclic AMP accumulation. The results show that iodide oxidation is required for its inhibitory action on cyclic AMP accumulation in human thyroid. |
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