| 6,7-二氢-5H-环戊烯并[b]吡啶的制备 |
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| 引用本文： | 冯泽旺,赵信岐. 6,7-二氢-5H-环戊烯并[b]吡啶的制备[J]. 中国医药工业杂志, 2007, 38(9): 621-622 |
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| 作者姓名： | 冯泽旺 赵信岐 |
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| 作者单位： | 1. 北京理工大学材料科学与工程学院,北京,100081;北京华禧联合科技发展有限公司,北京,102206
2. 北京理工大学材料科学与工程学院,北京,100081 |
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| 摘 要： | 1-氨基-2-氰基环戊烯经乙酰化、闭环和氯化反应制得4-氨基-2-氯-6,7-二氢-5H-环戊烯并[b]吡啶,再经Sandmeyer溴化和钯炭催化氢化脱卤制得6,7-二氢-5H-环戊烯并[b]吡啶,总收率为61%。
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| 关 键 词： | 6,7-二氢-5H-环戊烯并[b]吡啶 头孢匹罗 制备 中间体 |
| 文章编号： | 1001-8255（2007）09-0621-02 |
| 修稿时间： | 2007-06-05 |
Preparation of 6,7-Dihydro-5H-cyclopenteno[b]pyridine |
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| FENG Ze-wang,ZHAO Xin-qi. Preparation of 6,7-Dihydro-5H-cyclopenteno[b]pyridine[J]. , 2007, 38(9): 621-622 |
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| Authors: | FENG Ze-wang ZHAO Xin-qi |
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| Affiliation: | 1. School of Material Science and Engineering College, Beijing Institute of Technology, Beijing 100081; 2. Beijing Huaxi Technology Co., Ltd., Beijing 102206 |
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| Abstract: | 6,7-Dihydro-5H-cyclopenteno [b]pyridine was prepared from 1-amino-2-cyanocyclopentene by acetylation, cyclization and chlorination to give 4-amino-2-chloro-6,7-dihydro-5H-cyclopenteno [b] pyridine, which was subjected to Sandmeyer bromination and then catalytic hydrogenated dehalogenation with an overall yield of about 61%. |
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| Keywords: | 6,7-dihydro-5H-cyclopenteno [b] pyridine cefpirome preparation intermediate |
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