| Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia？ |
| |
| 引用本文： | Smit M,Dohle GR,Wildhagen MF,Weber RF. Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia？[J]. Asian journal of andrology, 2007, 9(3): 382-387 |
| |
| 作者姓名： | Smit M Dohle GR Wildhagen MF Weber RF |
| |
| 作者单位： | [1]Andrology Unit of the Department of Urology, Erasmus MC, 3000 CA Rotterdam, the Netherlands [2]Department of Urology and Gynecology, Erasmus MC, 3000 CA Rotterdam, the Netherlands |
| |
| 摘 要： | Aim： To evaluate whether inhibin-B can predict the outcome of a microsurgical epidymal sperm aspiration （MESA） procedure in patients with suspected primary obstructive azoospermia （OA） and if inhibin-B can replace testicular biopsy in the diagnostic work-up of these patients. Methods： Inhibin-B levels and testicular biopsy scores were related to the outcome of MESA in 43 patients with suspected primary OA. MESA was considered to be successful when epididymal sperm could be identified during the procedure. Results： Spermatozoa were present in the epididymal aspirate in 28 out of the 43 patients （65%）. lnhibin-B values were not significantly different in patients with successful or unsuccessful MESA. The modified Johnsen score, however, was significantly lower in patients with unsuccessful MESA （P = 0.003）. A rete testis obstruction or epididymal malfunctioning was found in 15% of patients with suspected primary OA, reflected by unsuccessful MESA despite normal inhibin-B levels and normal testicular histology. Conclusion： Inhibin-B cannot replace testicular biopsy as a diagnostic tool in the work-up of patients with suspected primary OA. Testicular biopsy is useful in identifying patients with spermatogenic arrest, who might have normal inhibin-B values.
|
| 关 键 词： | 原发性梗阻性无精子症 抑制素-B 预测 手术效果 微外科附睾精子抽吸术 |
| 修稿时间： | 2005-12-312006-06-16 |
Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia |
| |
| Smit Marij,Dohle Gert R,Wildhagen Mark F,Weber Rob F A. Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia[J]. Asian journal of andrology, 2007, 9(3): 382-387 |
| |
| Authors: | Smit Marij Dohle Gert R Wildhagen Mark F Weber Rob F A |
| |
| Affiliation: | Andrology Unit of the Department of Urology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. |
| |
| Abstract: | AIM: To evaluate whether inhibin-B can predict the outcome of a microsurgical epidymal sperm aspiration (MESA) procedure in patients with suspected primary obstructive azoospermia (OA) and if inhibin-B can replace testicular biopsy in the diagnostic work-up of these patients. METHODS: Inhibin-B levels and testicular biopsy scores were related to the outcome of MESA in 43 patients with suspected primary OA. MESA was considered to be successful when epididymal sperm could be identified during the procedure. RESULTS: Spermatozoa were present in the epididymal aspirate in 28 out of the 43 patients (65%). Inhibin-B values were not significantly different in patients with successful or unsuccessful MESA. The modified Johnsen score, however, was significantly lower in patients with unsuccessful MESA (P = 0.003). A rete testis obstruction or epididymal malfunctioning was found in 15% of patients with suspected primary OA, reflected by unsuccessful MESA despite normal inhibin-B levels and normal testicular histology. CONCLUSION: Inhibin-B cannot replace testicular biopsy as a diagnostic tool in the work-up of patients with suspected primary OA. Testicular biopsy is useful in identifying patients with spermatogenic arrest, who might have normal inhibin-B values. |
| |
| Keywords: | Inhibin B male infertility microsurgical epididymal sperm aspiration primary obstructive azoospermia |
| 本文献已被 维普 PubMed 等数据库收录！ |
