脑梗死患者血清PA轴激素与NSE水平的相关性分析

目的 :探讨脑梗死患者血清NSE水平与脑损伤程度及垂体 -肾上腺 (PA)轴激素的相关性。方法 :采用放射免疫分析测定 5 5例脑梗死患者血清ACTH、Cor及NSE水平。结果 :小面积梗死组血清ACTH水平略高于正常对照组 ,无显著差异 (p >0 0 5 ) ,中及大面积组水平升高更为显著 (p <0 0 1,p <0 0 1) ;病理组之间 ,小面积与中面积组和中面积与大面积组两配对组间差异亦极显著 (p <0 0 1,p <0 0 1)。Cor水平则小面积组显著高于正常对照组 (p <0 0 5 ) ,中及大面积组水平升高更甚 (p <0 0 1,p <0 0 1) ;病理组间 ,小面积与中面积和中面积与大面积两两配对组间差异也极其显著 (p <0 0 1,p <0 0 1)。NSE水平小面积组显著高于正常对照组 (p <0 0 5 ) ,中及大面积组水平均极显著高于正常对照组 (p <0 0 1,p <0 0 1) ;病理组间 ,小面积与中面积和中面积与大面积两配对组间水平也具显著性 (p <0 0 5 ,p <0 0 5 )。以中面积组NSE与ACTH及Cor分别行直线相关分析 ,结果两者间均呈显著正相关 (r =0 6 2 ,r =0 6 6 ;p <0 0 1,p <0 0 1) )。 结论 :NSE水平的升高与脑梗死的病情关系密切 ;而两项PA轴激素的测定对PA轴内分泌调节功能的评估有重要价值

Study on the Correlation Between Serum Levels of Pituitary-Adrenal Axial Stress Hormones and NSE in Patients with Cerebral Infarction

Objective To investigate the relationship between the serum levels of NSE and pituitary-adrenal axial hormones in patients with cerebral infarction as well as the relationship to the severity of brain injury. Methods Serum ACTH, contisol and NSE levels were determined with RIA in 55 patients with cerebral infarction and 35 controls. Results The serum ACTH levels in patients with small infarctions were only slightly higher than those in the controls (not significant, p >0 05). With medium and large infarctions, the increases were significant ( p <0 01, p <0 01). Comparing among the patients, levels in patients with medium lesions were significantly higher than those in patients with small lesions; the same held true between patients with large and medium lesions ( p <0 01, p <0 01). For cortisol and NSE, even in patients with small infarctions the serum levels were alrealy significantly higher than those in the controls (both p <0 05). Comparing the changes among the patient groups the results paralled those in the case with ACTH. In patients with medium lesions, the serum NSE levels were significantly positively correlated to the ACTH and cortisol levels respectively ( r=0 62,r =0 66, p <0 01, p <0 01). Conclusion Elevation of serum NSE levels was closely related to the severity of brain injury and was of prognsostic value. The same was true in the case with ACTH and cortisol.