| MiB—1的表达与早期胃癌临床病理及预后的关系 |
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| 引用本文： | 车向明,王康,帆北修一,爱甲孝. MiB—1的表达与早期胃癌临床病理及预后的关系[J]. 中国普外基础与临床杂志, 2001, 8(3): 145-147 |
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| 作者姓名： | 车向明 王康 帆北修一 爱甲孝 |
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| 作者单位： | 1. 西安交通大学第一医院普通外科
2. 日本鹿儿岛大学医学院第一外科 |
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| 摘 要： | 目的 研究早期胃癌MiB-1表达与临床病理的关系。方法 采用免疫组织化学法，对99例早期胃癌手术切除标本进行检测。结果 MiB-1增殖指数（MiB-1 PI）与患者年龄、肿瘤大小、部位及浸润深度有关。分化型腺癌MiB-1PI高于低分化腺癌（P＜0．01）；胃壁淋巴管浸润或淋巴结转移阳性肿瘤的MiB-1 PI较高（P＜0．05）。MiB-1增殖等级（MiB-1 PG)与患者术后生存率有关，MiB-1 PGⅠ、Ⅱ级术后生存高于Mib-1PGⅢ、Ⅳ级（P＜0．05）。结论 即使在胃癌早期，肿瘤的不同增殖水平亦与患者的预后直接相关。
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| 关 键 词： | MiB－1 早期胃癌 淋巴结转移 增殖指数 预后 |
| 文章编号： | 1007-9424(2001)03-0145-03 |
| 修稿时间： | 2001-01-04 |
MiB-1 EXPRESSION IN EARLY GASTRIC CANCER: ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS |
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| CHE Xiang-ming,WANG Kang,SHUICHI Hokita et al. MiB-1 EXPRESSION IN EARLY GASTRIC CANCER: ASSOCIATED WITH CLINICOPATHOLOGY AND PROGNOSIS[J]. Chinese Journal of Bases and Clinics In General Surgery, 2001, 8(3): 145-147 |
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| Authors: | CHE Xiang-ming WANG Kang SHUICHI Hokita et al |
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| Affiliation: | CHE Xiang-ming,WANG Kang,SHUICHI Hokita et al. Department of General surgery,First Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710061 |
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| Abstract: | Objective To study the relationship between early gastric cancer and MiB-1 expression. Methods Resected early gastric cancer from 99 cases were studied by immunohistochemical method. Results MiB-1 proliferation index (MiB-1 PI) was related to patient 's age, tumor size, location and depth of invasion. MiB-1 PI was higher in differentiated adenocarcinomas than in undifferentiated adenocarcinomas(P＜0.01). Cancers with lymphatic vessel invasion or lymph node metastasis had higher MiB-1 PI (P＜0.05). The postoperative survival was related to MiB-1 proliferation grade (MiB-1 PG), being higher in MiB-1 PG 1,2 grade than that in MiB-1 PG 3,4 grade. Conclusion Even in the early stage of gastric cancer, tumor proliferation activity was related to patients' prognosis. |
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| Keywords: | MiB-1 Early gastric cancer Lymph node metastasis Proliferation index Prognosis |
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