大黄素对牙周炎大鼠临床指标影响的实验研究

目的：观察中药大黄素对牙周炎大鼠临床指标的影响,探讨大黄素是否可以用于牙周炎的治疗。方法：健康雄性4月龄Wistar大鼠40只建立牙周炎模型,建模后随机分为四组,每组10只,P：模型对照组;P1：小剂量大黄素（80mg/kg）组;P2：大剂量（100mg/kg）大黄素组;P3：替硝唑（400mg/kg）组。分别于用药前及用药5天、10天、15天观察大鼠牙周探诊出血、探诊深度、附着丧失变化,分析两种剂量的大黄素与替硝唑组对大鼠临床指标的影响,比较其疗效。结果：两种剂量的大黄素对牙周炎大鼠牙周临床指标均有改善,大剂量大黄素组与替硝唑组对大鼠临床指标改善无显著性差异（P〉0.05）。结论：大黄素可改善牙周炎大鼠牙周状况。

The Influence of the Emodin to Clinic Index Changes of Experimental Periodontitis Rats

Objective：The experiment is to observe the effect of emodin,to clinic index in experimental periodontitis and approach the possibility as hreating medicine.Methods：Forty eight 4-month-old Wistar rats were formed experimental periodontitis,then divided into four groups at random：group P-assess the features of the model;group P1-the lower dosage of emodin which given 80mg/kg;P2-the high dosage of emodin which given 100mg/kg;group P3-fed tinidazole 400mg/kg.Measured the clinic index（PD、AL、BOP）once per five days as to experiment ending.Results：It suggested that two dosis emodin could progress the clinic index .Compared the improvement with the masc contol group and the dosis of 100mg/kg emodin,there is no statistically significant（P〉0.05）.Conclusion：Emodin could progress the experimental periodontitis rats.