Effects of conjugated estrogens on plasma butaperazine levels

A randomly assigned control-experimental grouping with a crossover design, using subjects as their own controls, was utilized to study the effects of conjugated estrogens on plasma butaperazine (Repoise) levels in post-menopausal female subjects. Significantly higher plasma butaperazine levels were measured following both a single loading dose and with maintenance doses of oral butaperazine in subjects when they were taking conjugated estrogens as compared to when they were not taking conjugated estrogens. The underlying mechanisms for these findings and their clinical implications are discussed briefly.This research was supported in part by grant GM 15431 from the National Institutes of Health, grant MH 11468 from the National Institute of Mental Health, and by research support from the State of Tennessee Department of Mental Health.