| 高效液相色谱法测定化妆品中三氯生 |
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| 引用本文： | 朱杰民,胡静,杨业,杜达安,梁旭霞.高效液相色谱法测定化妆品中三氯生[J].卫生研究,2000,29(3):154-155. |
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| 作者姓名： | 朱杰民 胡静 杨业 杜达安 梁旭霞 |
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| 作者单位： | 广东省卫生防疫站,广州,510300 |
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| 摘 要： | 采用高效液相色谱（ＨＰＬＣ，带有二级管阵列检测器）测定化妆品的杀菌剂三氯生。用Ｃ１８柱，以乙腈－水（６０：４０），用冰醋酸调节ｐＨ值３．０为流动相，检测波长２８０ｎｍ，以保留时间及紫外光谱图作定性，以峰面积或峰高作定量．该方法准确度和精密度较高，各类化妆品加标回收率范围为９１．９％～９８．８％，相对标准偏差范围为０．７２％～２．８％。
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| 关 键 词： | 高效液相色谱 杀菌剂 三氯生 化妆品 测定 |
Determination of trichlosan in cosmeticy by high-performance liquid chromatography |
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| Zhu Jiemin,Hu Jing,Yang Ye,Du Daan,et al..Determination of trichlosan in cosmeticy by high-performance liquid chromatography[J].Journal of Hygiene Research,2000,29(3):154-155. |
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| Authors: | Zhu Jiemin Hu Jing Yang Ye Du Daan |
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| Institution: | Health and Epidemic Preventive Station of Guangdong Province, Guangzhou 510300, China. |
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| Abstract: | A method was developed for the determination of an antiseptic-trichlosan in cosmeticy by HPLC followed by diode-array detection. The chromatographic separation was performed on C18 column with a mobile phase of acetonitrile-water(60: 40, V/V) which was adjusted to pH3.0 by glacialacetic acid. The UV wavelength was 280 nm. Retention time as well as UV spectrum were used for the qualitation of trichlosan, and peak area or peak height for quantitation. The method showed good accuracy and precision average recovery of trichlosan from different cosmetics was between 91.86% and 98.83%. Relative standard deviation was between 0.72% and 2.75%. |
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| Keywords: | high\|performance liquid chromatography diode\|array detection cosmetics anti\|bacterial agents trichlosan |
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