螺内酯对急性心肌梗死患者心功能综合指数的影响

目的探讨螺内酯对急性心肌梗死患者心功能综合指数（Tel指数）的影响。方法选择ST段抬高心肌梗死患者90例，采用随机数字表法分为螺内酯组和对照组各45例。对照组给予常规治疗，螺内酯组在对照组基础上口服螺内酯20mg／d，治疗6个月，治疗前后检测Tei指数并进行分析。结果治疗前2组患者的Tei指数比较，差异无统计学意义；治疗后螺内酯组的Tei指数为（0．53±0．16），明显低于对照组（0．62±0．14），差异有统计学意义（P〈0．05）。结论螺内酯可减低AMI后患者的Tel指数水平，具有改善心功能的作用。

The impact of spironolactone on Tel index in patients with acute myocardial infarction

Objectives To study the impact of spironolactone on Tei index in patients with acute myocardial infarction(AMI). Methods Ninety cases of patients with ST-segment elevation myocardial infarction were selected and randomly divided into two groups. Forty-five cases in control group were given routine therapy and 45 cases in spironoiactone group were given 20 mg spironolactone once a day on the basis of the same routine therapy as con-trois. The levels of Tei index were measured before and after the treatment of 6 months. Results There was no sig-nificant difference between two groups before treatment (P >0.05). After treatment Tel index of spironolactone group(0.53±0.16) was significantly lower than control group (0.62±0.14) (P<0.05). Conclusions Spironolactone can reduce the level of Tei index and improve the cardiac function of patients with AMI.