血管内皮生长因子C和受体3在子宫内膜异位症的表达及意义

目的:探讨血管内皮生长因子C(VEGF-C)和其受体3(VEGFR-3)在子宫内膜异位症(EMs)中的表达及其在EMs发病机制中的作用。方法:收集32例EMs患者的卵巢子宫内膜异位病灶组织、32例在位内膜组织和25例正常子宫内膜组织(对照组),应用免疫组化两步法检测各标本中的VEGF-C和VEGFR-3的表达,并用组织学评分对实验结果进行半定量统计,比较其表达强度。结果:VEGF-C在EMs组在位、异位内膜和对照组均有表达,表达强度差异无统计学意义(P>0.05);VEGFR-3在EMs组在位和异位内膜的表达明显高于对照组(P<0.05),且在位内膜的表达明显高于异位内膜(P<0.05)。结论:VEGF-C与其受体VEGFR-3结合参与了EMs病程,并可能通过促淋巴管新生作用而促进了EMs的发生发展。

Expression and significances of vascular endothelial growth factor-C and its receptor-3 in patients with endometriosis

Objective:To investigate the expression of VEGF-C and VEGFR-3 in endometriosis and the relationship between vascular endothelial growth factor and the mechanism of endometriosis. Methods:A total of 32 specimens of endometriosis and 25 specimens of the normal controls were evaluated by immunohistologically technique with polyclonal antibody against VEGF-C and VEGFR-3.Results:VEGF-C expressed express either in normal endometrium or eutopic and ectopic endometrium of endometriosis. There were no significant differences between them (P>0.05).The expression levels of VEGFR-3 in eutopic and ectopic endometrium of endometriosis were significantly higher than that of normal endometrium (P<0.05). The expression of VEGFR-3 in eutopic endometrium was higher than that in ectopic endometrium (P<0.05).Conclusion:VEGF-C and VEGFR-3 play significant roles in the regulation of lymphangiogenesis of endometriosis, which express in both eutopic endometrium and ectopic endometrium of endometriosis. VEGF-C and VEGFR-3 may play vital roles in the pathogenesis and development of endometriosis.