| 苦参汤中生物碱部位的化学成分 |
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| 引用本文： | 刘斌,石任兵.苦参汤中生物碱部位的化学成分[J].中国中药杂志,2006,31(7):557-560. |
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| 作者姓名： | 刘斌 石任兵 |
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| 作者单位： | 北京中医药大学,中药学院,北京,100102 |
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| 摘 要： | 目的:研究苦参汤中生物碱部位的化学成分。方法:采用各种色谱法分离,运用多种波谱技术鉴定结构。结果:分离鉴定出8个化合物:苦参碱(matrine,Ⅰ)、槐定碱(sophoridine,Ⅱ)、槐果碱(sophocarpine,Ⅲ)、槐胺碱(sophoramine,Ⅳ)、氧化苦参碱(oxymatrine,Ⅴ)、氧化槐果碱(oxysophocarpine,Ⅵ)、苦豆碱(aloperine,Ⅶ)和鹰爪豆碱(sparteine,Ⅷ)。结论:这些化合物均为首次从苦参汤中分离得到,苦豆碱为首次在组成苦参汤复方的3味中药苦参、生地黄、黄芩中发现。
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| 关 键 词： | 苦参汤 生物碱 |
| 文章编号： | 1001-5302（2006）07-0557-04 |
| 收稿时间： | 2005-05-10 |
| 修稿时间： | 2005-05-10 |
Constituents in the alkaloid fraction of Kushen decoction |
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| LIU Bin;SHI Ren-bing.Constituents in the alkaloid fraction of Kushen decoction[J].China Journal of Chinese Materia Medica,2006,31(7):557-560. |
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| Authors: | LIU Bin;SHI Ren-bing |
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| Institution: | School of Chinese Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China |
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| Abstract: | OBJECTIVE: To study the chemical constituents of the alkaloid fraction of Kushen decoction. METHOD: Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods. RESULT: Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII). CONCLUSION: All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction. |
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| Keywords: | Kushen decoction alkaloids |
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