慢性乙型肝炎及慢性丙型肝炎患者混合感染GBV-C的队列研究

目的 探讨GB病毒C(GBV-C)的致病性,以及混合感染GBV-C后对慢性乙型肝炎及慢性丙型肝炎预后的影响.方法 对我国河南省某市95例慢性乙型肝炎患者及某农村80例慢性丙型肝炎患者进行了现况调查,并于其后6个月及20个月进行前瞻性队列研究.结果 GBV-C混合感染率在慢性乙型肝炎患者中为20.0%～25.0%,在慢性丙型肝炎患者中为28.3%～33.5%.混合感染GBV-C后,对于慢性肝炎患者的肝功能水平未产生显着影响.结论 表明在慢性乙型肝炎和慢性丙型肝炎患者中,未发现混合感染GBV-C明显加重肝损伤,故不支持GBV-C有明显的嗜肝致病性.

Cohort Study on Pathogenicity of Hepatitis G Virus Mixed Infection with Hepatitis B and C Virus

Objective To study the pathogenicity of GB virus C(GBV-C),and effect of coinfection with GBV-C on hepatitis B and C.Methods GBV-C was determined in sera of 95 patients who were diagnosed as chronic hepatitis B and 80 patients of hepatitis C.Co hort study for 6,20 months was conducted.Results The rate of HBV and GBV-C mixed infection was 20,0%~25,0% and rate of HCV and GBV-C mixed infection was 28.3%~33.5%.Serum ALT,AST,TBil,etc were compared between with and without GBV-C infecton.No significant difference was found between the two groups.GBV-C did not effect the clearance of HBV and HCV.Conclusion The study suggested that mixed infection of GBV-C did not lead to significant effect on patients with chronic hepatitis B and hepatitis C.It was lack of pathogenicity that GBVC existed in liver disease.