乙型肝炎肝硬化失代偿期与酒精性肝硬化失代偿期患者血小板参数变化的临床分析

目的探讨不同HBV DNA水平乙型肝炎肝硬化失代偿期与酒精性肝硬化失代偿期血小板计数（PLT）及血小板平均体积（MPV）变化的临床意义。方法对36例健康人、38例HBV DNA〈105拷贝/ml乙型肝炎肝硬化失代偿期患者、36例HBV DNA〉105拷贝/ml乙型肝炎肝硬化失代偿期患者及31例酒精性肝硬化失代偿期患者的外周血PLT及MPV进行测定及分析。结果与健康人相比,乙型肝炎肝硬化及酒精性肝硬化患者PLT均下降,差异有统计学意义（P〈0.05）;与酒精性肝硬化失代偿期患者相比,HBV DNA〉105拷贝/ml乙型肝炎肝硬化失代偿期患者PLT下降,差异有统计学意义（P〈0.05）;不同HBV DNA水平的乙型肝炎肝硬化失代偿期患者PLT均下降,差异有统计学意义（P〈0.05）。与健康人相比,酒精性肝硬化失代偿期、HBV DNA〉105拷贝/ml乙型肝炎肝硬化失代偿期患者MPV均下降,差异有统计学意义（P〈0.05）;与酒精性肝硬化失代偿期患者相比,HBV DNA〉105拷贝/ml乙型肝炎肝硬化失偿代期患者MPV下降,差异有统计学意义（P〈0.05）;不同HBV DNA水平的乙型肝炎肝硬化失代偿期患者MPV变化,差异有统计学意义（P〈0.05）。结论乙型肝炎肝硬化失代偿期患者高载量HBV DNA对血小板参数降低有一定的影响。

Clinical analysis on changes of platelet parameters in patients with decompensated liver cirrhosis of hepatitis B and alcoholic cirrhosis

Objective To explore the changes of platelet parameters：platelet（PLT） ,mean platelet volume（MPV） in patients with decompensated liver cirrhosis of hepatitis B with different HBV DNA levels and alcoholic liver cirrhosis.Methods Platelet parameters：PLT and MPV of 36 healthy people（control group） ,38 cases of decompensated liver cirrhosis of hepatitis B with HBV DNA 105copies/ml,36 cases of decompensated liver cirrhosis of hepatitis B with HBV DNA 105copies/ml and alcoholic liver cirrhosis were examined and analyzed by test.Results PLT of patients with decompensated liver cirrhosis of hepatitis B and alcoholic liver cirrhosis descended evidently compared with control group（P 0.05） .PLT of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA 105copies/ml descended evidently compared with decompensated liver cirrhosis of alcohol（P 0.05） .PLT of patients with decompensated liver cirrhosis of hepatitis B with different HBV DNA levels descended evidently（P 0.05） .MPV of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA 105copies/ml and alcoholic liver cirrhosis descended evidently compared with control group（P 0.05） .MPV of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA 105copies/ml descended evidently compared with decompensated liver cirrhosis of alcohol（P 0.05） .MPV of patients with decompensated liver cirrhosis of hepatitis B with different HBV DNA levels descended evidently（P 0.05） .Conclusions High HBV DNA level in patients with decompensated liver cirrhosis of hepatitis B may have effect on the decrease of PLT.