水飞蓟宾治疗非酒精性脂肪性肝炎临床疗效观察

目的评价水飞蓟宾胶囊治疗非酒精性脂肪性肝炎（NASH）的临床疗效。方法非酒精性脂肪性肝炎患者72例,随机分为两组。治疗组40例给予水飞蓟宾治疗,对照组32例服用护肝片治疗,疗程均为12周。测定治疗前后两组患者血清酶学、血脂及腹部超声变化,并记录患者临床症状。结果治疗后两组临床症状、血清酶学、血脂及脂肪肝程度差异均有统计学意义,未发现明显不良反应。结论水飞蓟宾胶囊治疗NASH可改善患者临床症状,降低血清转氨酶及血脂,减轻肝内脂肪沉积,具有显著疗效且用药安全。

Clinical effect of silymarin on cases with nonalcoholic steatohepatitis

Objective To assess the clinical effect of silymarin on cases with nonalcoholic steatohepatitis（NASH） .Methods Total of 72 cases with NASH were randomly divided into two groups,the 40 cases of treatment group were treated with silymarin capsules,70 mg,three times a day,while 32 cases of control group were treated with liver protect tablets,four tablets,three times a day.Both groups were treated for 12 weeks.Differences of serum enzymes,blood fat and abdominal type-B ultrasonic before and after therapy were tested and the improvement in clinical symptoms were recorded.Results A significant improvement of clinical symptoms,serum enzymes,blood fat and abdominal type-B ultrasonic after treatment were found in both groups（P 0.05） .There were no significant drug adverse reactions.Conclusions Silymarin capsule is effective and safe for improvement of clinical symptoms,and can decrease serum enzymes and blood fat in patients with NASH.