| 补肾健脾活血法对超排卵小鼠种植窗期子宫内膜LIF表达的影响 |
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| 引用本文： | 陈瑾,陈晓勇,王振迎. 补肾健脾活血法对超排卵小鼠种植窗期子宫内膜LIF表达的影响[J]. 中国妇幼保健, 2011, 26(13): 2024-2027 |
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| 作者姓名： | 陈瑾 陈晓勇 王振迎 |
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| 作者单位： | 1. 江西省妇幼保健院,江西,南昌,332006
2. 南昌大学研究生院医学部 |
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| 摘 要： | 目的:观察补肾健脾活血法对超排卵小鼠子宫内膜白血病抑制因子(LIF)表达的影响。方法:雌性小鼠予阿拉瑞林/孕马血清促性腺激素/人绒毛膜促性腺激素构建超排卵小鼠模型,并随机分成实验组(中药组)、阳性对照组(阿司匹林组)、阴性对照组,分别给予补肾健脾活血中药、阿司匹林、0.9%氯化钠注射液进行干预。在小鼠种植窗期取子宫中段组织,用逆转录-PCR(RT-PCR)法检测小鼠子宫内膜组织中LIF mRNA的表达水平。结果:中药组与阿司匹林组超排卵小鼠子宫内膜LIF mRNA的表达均明显高于阴性对照组,差异有显著统计学意义(P<0.01);中药组LIF mRNA的表达高于阿司匹林组,差异有统计学意义(P<0.05)。结论:补肾健脾活血法可以提高超排卵状态下子宫内膜LIF mRNA的表达水平,改善超排卵状态下子宫内膜的容受性,效果优于阿司匹林。
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| 关 键 词： | 补肾健脾活血法 控制性超排卵 小鼠 种植窗期 子宫内膜容受性 白血病抑制因子 |
Effect of strengthening spleen and kidney and activating blood method on the expression of LIF in endometrium of controlled ovarian hyperstimulation mice at implantation window stage |
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| CHEN Jin,CHEN Xiao-Yong,WANG Zhen-Ying. Effect of strengthening spleen and kidney and activating blood method on the expression of LIF in endometrium of controlled ovarian hyperstimulation mice at implantation window stage[J]. Maternal and Child Health Care of China, 2011, 26(13): 2024-2027 |
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| Authors: | CHEN Jin CHEN Xiao-Yong WANG Zhen-Ying |
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| Affiliation: | CHEN Jin,CHEN Xiao-Yong,WANG Zhen-Ying.Maternal and Child Health Hospital of Jiangxi,Nanchang 332006,Jiangxi,China |
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| Abstract: | Objective:To observe the effect of strengthening spleen and kidney and activating blood method on the expression of leukemia inhibiting factor(LIF) in endometrium of controlled ovarian hyperstimulation(COH) mice at implantation window stage.Methods:The female mice were used to establish mouse models of COH by treated with Alarelin,pregnant mare serum gonadotrophin and human chorionic gonadotropin,then the mice were divided into experimental group(traditional Chinese medicine group,the mice were treated with... |
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| Keywords: | Strengthening spleen and kidney and activating blood method Controlled ovarian hyperstimulation Mouse Implantation window phase Receptivity of endometrium Leukemia inhibiting factor |
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