RS3PE综合征与肿瘤相关性的探讨(附八例报告)

目的 了解缓和性血清阴性对称性滑膜炎伴凹陷性水肿综合征(RS3PE)的临床特点及与肿瘤的关系。方法 回顾分析8例RS3PE患者的临床表现、实验室检查资料，并复习有关文献。结果 8例均表现为双手及双足的突发性肿胀，血清类风湿因子阴性。8例均有不同肿瘤标记物阳性，其中3例合并肿瘤。结论 8例RS3PE综合征与肿瘤有相关性。

Study in remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome associated with malignancies:a review of literatures and a report of 8 cases

Objective To study the clinical features and diagnosis of RS 3PE syndrom and its association with malignancies.Methods The clinical manifestations and laboratory parameters of 8 patients with RS 3PE syndrome from our hospital were analyzed and the related literatures were reviewed.Results The main clinical features of the 8 patients were symmetrical polysynovitis of acute onset involving most of their appendicular joints and flexor digitorum tendons associated with pitting edema of the dorsum of both hands and both feet.Rheumatoid factor (RF) of serum were absert in all and no radiologically evident erosions developped.8 patients had various tumor markers.Three of them suffered from malignancies.Treatment consisted of prednisone.MTX and NSAIDs,symptoms were controlled rapidly.Conclusions RS 3PE may not be a rare syndrome.It is suggested that RS 3PE might have a close relationship with malignancies.