慢性前列腺炎细菌及免疫学研究

目的　了解慢性前列腺炎细菌感染情况 ,提高治疗水平。　方法　对 132例慢性前列腺炎患者行尿及前列腺液细菌五步培养法、药物敏感试验及前列腺液免疫球蛋白IgA和lgG测定 ,并根据药敏试验结果对部分患者进行治疗。　结果　前列腺液细菌培养阳性者 74例 ,其中金黄色葡萄球菌 32例 (耐药金黄色葡萄球菌 5例 ) ,表皮葡萄球菌 17例 ,大肠杆菌 10例 ,其它细菌 15例 ;细菌培养阴性者 5 8例。细菌培养阳性者前列腺液中IgG和IgA分别平均为 1.12 g/L和 0 .32 g/L(n =34 ) ,显著高于细菌培养阴性者 (0 .2 3g/L和 0 .0 2 g/L ,n =37;P =0 .0 31和P =0 .0 36 )。　结论　慢性前列腺炎患者前列腺液细菌培养阳性率较高 (5 6 .1% ) ,以革兰阳性菌多见 (6 6 .2 % ) ,细菌可能来源于女性生殖道。下尿路细菌定位诊断可简化为“两杯法”。前列腺液细菌培养阳性者的前列腺液中免疫球蛋白IgG和IgA水平较高

A pathogenic and immunologic study of chronic prostatitis

Objective To investigate the bacterial pathogenesis in chronic prostatitis. Methods The prostatic fluid of 132 patients was studied with "five glass"segmented lower urinary tract localization culture test and measurement of IgA and IgG levels.Some bacteria positive cases were treated with levofloxacin. Results 74 patients were bacteria positive in their prostates,32 had Staphylococcus aureus,17 with Staphylococcus epidermidis,10 cases had Escherichia coli and 15 with other bacteria IgG and IgA levels were significantly higher ( P =0.031 and P =0.036) in bacteria positive prostatic fluid than in bacteria negatives ones. Conclusions The positive rate of bacteria culture in the prosatic fluid of patients with chronic prostatitis was high (56.1%) and Gram positive bacterias were more common.These pathogens may come from the partners reproductive tract.The levels of IgA and IgG in prostatic fluid were correlated to the results of bacteria culture.