Human parathyroid hormone does not influence human erythropoiesis in vitro |
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Authors: | Komatsuda A; Hirokawa M; Haseyama T; Horiuchi T; Wakui H; Imai H; Miura A |
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Institution: | Third Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita-shi, Akita 010-8543, Japan; Corresponding author |
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Abstract: | Background. Although renal anaemia is associated with
secondary hyperparathyroidism, the relationship of both conditions remains
obscure. Previously it was reported that high levels of bovine parathyroid
hormone (PTH) did not inhibit in vitro human
erythropoiesis, but whether human PTH inhibits in
vitro human erythropoiesis has not been determined.
Method. To clarify the direct effects of human
biologically active N-terminal (1-34) PTH and intact (1-84) PTH on human
haematopoietic progenitor growth, we investigated colony assays of human
erythropoiesis and granulomonopoiesis. Results.
Neither N-terminal PTH (300 ng/ml) nor intact PTH (5000 pg/ml) inhibited
haematopoietic progenitor growth. Conclusion. Our
findings confirm that human PTH does not directly inhibit human
erythropoiesis. |
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