Eicosanoid production by density-defined human peritoneal macrophages during inflammation |
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| Authors: | W. M. Pruimboom M. J. Vollebregt F. J. Zijlstra I. L. Bonta J. H. P. Wilson |
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| Affiliation: | (1) Department of Pharmacology, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam;(2) Department of Internal Medicine II, Academic Hospital Dijkzigt, Rotterdam, The Netherlands |
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| Abstract: | Density-defined macrophages isolated from fluids of patients with liver cirrhosis mainly generated the 5-lipoxygenase products leukotriene B4 (LTB4, 16%) and 5-hydroxy-eicosatetraenoic acid (5-HETE, 24%) and the cyclooxygenase products 12-hydroxyheptadecatrienoic acid (HHT, 22%) and thromboxane B2 (TXB2, 18%). The synthesis of eicosanoids was linear with the maturity of the macrophage subpopulations, suggesting that eicosanoid production is increased inin-vivo activated macrophages. |
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