先天性心脏病心肌超微结构与临床对比观察

对２５例法乐四联症，１１例室间隔缺损４例非心脏病患者的右心室心肌进行超微结构观察，并与临床资料对比分析，发现心肌细胞横径与病程，右心室平均压及室间隔缺损直径呈正相关，并观察到６例萎缩心肌中，５例以Ｚ带样物质积聚，肌原纤维紊乱为特征，另１例表现为线粒体大量增生，充满胞质，并对上述改变在先天性心脏病心肌病理中的意义进行了讨论。

Comparison of the ultrastructural and clinical studies on myocardium of patients with congenital heart disease

ight ventricle myocardium of 25 cases of tetralogy of Fallot and 11 cases of ventricle septal defect were studied by both light and electron microscopy. Normal human myocardium from 4 cases were used as the control. The resulting data indicate that the mean muscle diameter correlated significantly with the course of disease,mean pressure of right ventricle and diameter of ventrical septal defect.In 6 cases with congenital heart disease,the myocardium was atrophic and presented with 2 types of ultrastructural fea-tures:accumulation of Z- line material or hyperplasia of the mitochondria. The significance of these ultrastructural findings in congenital heart disease is discussed.