| 急性淋巴细胞白血病P16基因纯合子缺失的研究 |
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| 引用本文： | 黄毓,甘登仕,薜小霞.急性淋巴细胞白血病P16基因纯合子缺失的研究[J].广西医科大学学报,2000,17(1):26-27. |
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| 作者姓名： | 黄毓 甘登仕 薜小霞 |
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| 作者单位： | 广西医科大学第一附属医院!南宁530021 |
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| 摘 要： | 为了解Ｐ１６ｇｅｎｅ变异与急性淋巴细胞白血病（ＡＬＬ）发生发展的关系。方法：采用差别ＰＣＲ分析了３０例ＡＬＬ骨髓ＤＮＡ和１５例非恶性血液病骨髓ＤＮＡＰ１６ｇｅｎｅ纯合缺失。结果：３０例ＡＬＬ患者骨髓ＤＮＡ有１０例Ｐ１６ｇｅｎｅ Ｅｘｏｎ２纯合缺失，纯合缺失率为３３．３％。结论：Ｐ１６ｇｅｎｅ变异可能是ＡＬＬ发生发展中的重要因素。
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| 关 键 词： | 急性淋巴细胞性白血病 P16基因 基因纯合子缺失 |
| 修稿时间： | 1998-08-10 |
HOMOZYGOUS DELETION OF MTS1/P~(16) GENE IN ACUTE LYMPHOBLAS-TIC LEUKEMIA |
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| Huang Yu,Gan Dengshi,Xue Xiaoxia.HOMOZYGOUS DELETION OF MTS1/P~(16) GENE IN ACUTE LYMPHOBLAS-TIC LEUKEMIA[J].Journal of Guangxi Medical University,2000,17(1):26-27. |
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| Authors: | Huang Yu Gan Dengshi Xue Xiaoxia |
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| Abstract: | Objective:To investigate the alteration of MTS1/P 16 gene in acute lymphoblastic leukemia Methods:A total of 45 marrow DNA specimens,composed of 30 acute lymphoblastic leukemia and 15 controls marrow DNA specimens,were examined for homozygous deletion of MTS1/P 16 gene in by Differential PCR Results:The results showed that no deletions were detected in 15 controls marrow DNA examples However,10 of 30 acute lymphoblastic leukemia marrow DNA specimens were found by differential PCR with a 33 3%(10/30) WTS1/P 16 gene deletion rate Conclusion:The result suggests that MTS1/P 16 gene alteration may be an important event in the progression of acute lymphoblastic leukemia |
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| Keywords: | acute lymphoblastic leukemia suppressive gene MTS1/P~(16) gene |
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