| 庆大霉素前庭损害报警耳聋的实验研究 |
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| 引用本文： | 郭毓卿,丁大连,王泉良,朱惠珍. 庆大霉素前庭损害报警耳聋的实验研究[J]. 中国中西医结合耳鼻咽喉科杂志, 2000, 8(3): 108-110 |
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| 作者姓名： | 郭毓卿 丁大连 王泉良 朱惠珍 |
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| 作者单位： | 上海第二医科大学附属第九人民医院耳鼻咽喉科研究室!200011(郭毓卿，王泉良，朱惠珍)，上海第二医科大学耳科研究室(丁大连) |
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| 摘 要： | 目的观察庆大霉素对前庭及耳蜗的损害。方法对肌肉注射庆大霉素（250mg·kg－1／d）连续3天和7天的两组豚鼠进行前庭和耳蜗功能与形态的观察。结果发现用药3天仅影响前庭，而用药7天则前庭和耳蜗均受损害，提示庆大霉素早期损害前庭的特点可以报警耳蜗的损害。结论因此，在应用庆大霉素过程中，发现前庭功能改变时，如能及时停药，可以避免耳聋的发生。
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| 关 键 词： | 庆大霉素 前庭 耳毒性 耳聋 |
Experimental observation on Gentamycin vestibular damage alarming deafness |
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| Guo Yuqing, Ding Dalian, Wang Quanliang et al. Experimental observation on Gentamycin vestibular damage alarming deafness[J]. Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2000, 8(3): 108-110 |
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| Authors: | Guo Yuqing Ding Dalian Wang Quanliang et al |
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| Abstract: | Objective To observe the in jury of vestibular and cochlear end organ causedby Gentamycin. Method Two groups of guinea pigs, one were intramuscularly injected withGentamycin in a dosage of 250mg/kg per day for a continuous 3 days and the other for a continu-ous 7 days. Then all animal's vestibular and cochlear functions were tested and the cochleas wereharvested for a pathological examination. Result We found that guinea pigs had only vestibulardisfunction in 3 day group and had both vestibular and cochlear disorders in 7 day group- Thepathological findings were also consistent with the tested results. It seems that the early vestibu-lar in jury produced by Gentamycin can be as a sign of sensory-neural deafness. Conclusion Inclinical Gentamycin administration, it is very important to stop administrating immediately whenvestibular symptoms appear, otherwise, an unavoidable deafness will be followed.[ |
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| Keywords: | Gentamicin Vestibule Ototoxity |
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