脑卒中患者载脂蛋白H与血脂关系的研究

目的　探讨脑卒中患者载脂蛋白H(ApoH)血清水平与血脂的相关性以及ApoH与脑卒中的关系。方法　采用放射免疫法检测急性动脉粥样硬化性血栓性脑梗死 (ACI)患者 33例和急性高血压性脑出血 (ACH)患者 2 8例的ApoH血清水平 ,酶法测定血脂各项。结果　ACI、ACH患者与健康对照组血清ApoH水平分别为 2 88mg/L± 85 4mg/L、2 4 8mg/L± 6 8mg/L、2 5 6mg/L± 71mg/L。ACI患者的ApoH血清水平与胆固醇 (CHO)、低密度脂蛋白 (LDL)呈正相关 (r=0 394 ,P <0 0 5 ;r =0 394 ,P<0 0 5 ) ,与TG无相关性。 17例有家族史的脑卒中患者血清ApoH与高密度脂蛋白相关。结论　ApoH血清水平与ACI患者的CHO、LDL相关 ,与正常人及ACH患者无相关性。

Relationship between apolipoprotein H and lipid in stroke patients

OBJECTIVE: To study the correlation of serum apolipoprotein H (ApoH) with blood lipids and the relationship between ApoH and stroke. METHODS: The serum levels of ApoH of 33 patients with acute cerebral infarction (ACI), 18 patients with acute cerebral hemorrhage (ACH), 17 patients with cerebral apoplexy and family history, and 33 healthy control were measured by radioimmunoassay. The blood lipids of the above mentioned subjects were measured by enzymological methods. RESULTS: The serum ApoH levels in acute cerebral infarction (ACI) patients, acute cerebral hemorrhage (ACH) patients, and healthy controls were 288 +/- 85 mg/L, 248 +/- 68 mg/L, and 256 +/- 71 mg/L respectively. There was a significant correlation between serum ApoH and total CHO and between ApoH and LDL in ACI patients (r = 0.394, P < 0.05; r = 0.394, P < 0.05). However, no correlation between ApoH and triglyceride was found. In 17 cases of cerebral apoplexy with familial history, the serum ApoH was correlated with HDL. CONCLUSION: Serum ApoH is correlated with CHO and LDL in ACI patients. No such correlation can be found in healthy persons and ACH patients.