急性心肌梗塞溶栓后神经肽γ、一氧化氮、超氧化物歧化酶、丙二醛含量的变化

目的:探讨急性心肌梗塞(AMI)患者溶栓前、后血清神经肽γ(NPY)、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)的含量变化及临床意义。方法:测定108例健康人和171例AMI患者溶栓前及溶栓后1、2、3、24、48和72 h血清中NPY、NO、SOD和MDA的含量。结果:与健康人比较,溶栓前患者NPY和MDA含量升高,NO和SOD含量降低(P<0.05)。溶栓后1~3 h的再通组与溶栓前及未通组比较,NPY和MDA含量更高,而NO和SOD含量更低(P<0.01)。再通组的NPY和MDA高峰和NO和SOD的低谷均出现在溶栓后2 h。溶栓24 h后再通组NPY和MDA含量下降,而NO和SOD含量升高(P<0.05),其变化幅度大于未通组(P<0.01)。结论:AMI溶栓1~3 h内NPY和MDA明显升高,NO和SOD明显下降,可能与溶栓后早期内皮功能损伤有关。

Change of serum NPY, NO, SOD and MDA levels after thrombolytic therapy in patients with acute myocardial infarction

Objective:To study the changes of serum levels of neuropeptide Y(NYP),nitrogen monoxidum(NO),superoxide dismutase(SOD) and malonaldehyde(MDA) before and after thrombolytic therapy(TT) in patients with acute myocardial infarction(AMI).Methods:Serum concentrations of NPY,NO,SOD and MDA were detected before and after thrombolytic therapy at 1,2,3,24,48,and 72 h in AMI patients(n=171) and health people(n=108,as control).Results:Compared with healthy people,concentrations of NPY and MDA increased and NO and SOD decreased significantly before thrombolytic therapy(P<0.05).NPY and MDA were higher,NO and SOD were lower after successful therapy at 1 to 3 h than those before therapy or after failure to TT(P<0.05).The highest level of serum NPY and MDA,and the lowest level of serum NO and SOD appeared at 2h after TT(P<0.01);Then NPY and MDA decreased and NO and SOD increased significantly 24 h after TT in patients underwent TT successfully,compared with failure therapy group.Conclusion:Serum level of NPY and SOD increased and NO and SOD decreased significantly after successful thrombolytic therapy for AMI,which may be associated with endothelium injury induced by thrombolytic therapy.