A hereditary abnormal c-fms proto-oncogene in a patient with acute lymphocytic leukaemia and congenital hypothyroidism |
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| Authors: | J. S. Verbeek H. van Heerikhuizen B. E. de Pauw C. Haanen H. P. J. Bloemers W. J. M. Van de Ven |
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| Affiliation: | Departments of Biochemistry and Haematology, University of Nijmegen, Nijmegen;Department of Biochemistry, Free University, Amsterdam, The Netherlands |
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| Abstract: | A patient with congenital hypothyroidism and acute lymphocytic leukaemia was found to be homozygous for a 0.4 kbp deletion in the c-fms proto-oncogene. This was established by studying DNA from the patient's leukaemic cells, from cultured skin fibroblasts of the patient and from normal white blood cells of both parents. The uncertain relevance of this finding to the condition of the patient is discussed. |
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