瑞芬太尼预防丙泊酚注射痛

目的:探讨输注瑞芬太尼是否能有效地预防丙泊酚注射痛。方法:93例择期手术的病人随机分为A、B、C3组,每组31例。A组用药为瑞芬太尼0.3μg/kg;B组用药为2%利多卡因40mg;C组为对照组用生理盐水2ml。用VAS法对各组丙泊酚注射痛进行评分。观察各组对丙泊酚注射痛的影响。结果:C组注射痛的发生率为70.9%,与C组相比A组(25.8%;P<0.01)及B组(29.0%;P<0.01)注射痛的发生率明显减少。与C组相比A组及B组的疼痛评分差异显著(P<0.01),A与B两组间差异不显著。结论:瑞芬太尼与利多卡因一样可有效地预防注射痛,与丙泊酚配合使用可成为一种新的静脉麻醉方法。

Prevention of propofol - induced injection pain by remifentanil

Objective:To explore whether continuous remifentanil infusion can prevent injection pain effectively.Methods:93 patients scheduled for elective surgery were randomized into three groups with 3l each.Group A received remifentanil 0.3 μg/kg,group B received 2% lidocaine 40 mg and group C (placebo group) received 0.9% saline 2 ml.the injection pain was evaluated using VAS.Results:The incidence of injection pain was 70.9% in group C and,reduced significantly in group A(25.8%; P<0.01) and group B(29%;P<0.01).Analysis of the pain scores showed a significant difference between group A and group C(P<0.01) as well as between group B and group C(P<0.01).There was no significant difference between group A and group B.Conclusion:Remifentanil like lidocaine provides effective pain relief,combinding with propofol may be a new intravenous anaesthesia method.