The effect of donor/recipient body surface area ratio on outcomes in pediatric kidney transplantation

Abstract:  In pediatric kidney transplantation, the effect of inadequate nephron dosing on graft survival remains undetermined. The aim of this study was to assess the use of D/R BSA, as a reliable indicator of adequate nephron dosing, and eventually a tool to optimize pediatric graft allocation. Following Institutional Review Board approval, we reviewed deceased donor pediatric kidney transplantation (N = 156). We divided patients into three groups, based on D/R BSA: A ≤0.8; B 0.81–1.19; C ≥1.2. Five-yr graft survival rates in the groups were: A 82.0%; B 94.9%; C 97.1% (p   =   0.01). Group C had the lowest rate of acute rejection, suggesting a protective effect of increased D/R BSA (group A = 35.7%, group B = 38.9%, group C = 18.8%; p   =   0.029). The logistic regression analysis showed that decreased D/R BSA ratio is a risk factor for loss of graft function, at one and five yr i.e., group A OR 6 (95% CI 1.14–39.30, p   =   0.015) and OR 4.49 (95% CI 1.46–13.79, p = 0.009), respectively]. We conclude that for pediatric recipients, D/R BSA is a valuable adjunct when determining long-term graft survival. Its utility may avoid an alloimmune-independent risk factor, increasing the long-term protective value of a good matching policy.