超敏C反应蛋白和LDL-C联合检测在诊断2型糖尿病并发大血管病变中的意义

目的 通过观察血清超敏C反应蛋白（HS-CRP）及低密度脂蛋白胆固醇（LDL-C）水平在2型糖尿病并发大血管病变中的变化，探讨其对糖尿病并发大血管病变监测的应用价值。方法 收集60例2型糖尿病患者及50例正常体检者血清，全自动生化仪检测Hs—CRP、甘油三酯（TG）、LDL-C、总胆固醇（TC）、HDL-C、载脂蛋白（apoA1）、apoB。结果 糖尿病患者无论有无大血管并发症其Hs—CRP、TG、LDL-C水平均明显高于对照组（P〈0．05），大血管并发症组Hs—CRP、LDL-C水平明显高于无并发症组（P〈0．05）。大血管并发症组血清Hs—CRP水平与LDLC水平呈明显正相关（r=0．67，P〈0．05），而在无大血管并发症组，Hs-CRP表达水平与LDL-C及其他血脂指标均无明显相关性。结论 Hs—CRP及LDL-C联合检测可作为糖尿病及糖尿病并发大血管损伤的监测指标。

Combinative monitoring of Hs-CRP and LDL-C on type 2 diabetes with vascular complications

Objective To investigate the relationship between Hs-CRP,LDL-C and type 2 diabetes with vascular complications.Methods The levels of Hs-CRP,TG,LDL-C,TC,HDL-C,apoA1,apoB were detected on 60 diabetes patients with/without vascular complications and 50 healthy subjects.Results Compared with those of control group,the concentrations of CRP,TG and LDL-C were higher significantly in diabetes group;the levels of Hs-CRP and LDL-C in diabetes with vascular complications were higher than those of without complications;the pattern of Hs-CRP and LDL-C expression in diabetes with vascular complications showed a statistically significant correlation.Conclusion Combinative monitoring of Hs-CRP and LDL can be used to predict diabetes with vascular complications.