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| 癌宁对人胃腺癌细胞SGC—7901细胞因子及Fas基因表达的影响 | |
| 引用本文： | 苏勉诚,戴萍,吕晓英,万斌,李红坤,刘继林.癌宁对人胃腺癌细胞SGC—7901细胞因子及Fas基因表达的影响[J].现代预防医学,2001,28(1):6-7. |
| 作者姓名： | 苏勉诚 戴萍 吕晓英 万斌 李红坤 刘继林 |
| 作者单位： | 1. 珠海丽珠集团国家中药中心 2. 重庆市第三人民医院药剂科 3. 成都军区军事医学研究所 4. 成都中医药大学 |
| 摘 要： | 目的：探索癌宁对体外人胃癌细胞基因及细胞因子表达的影响。方法：采用流式细胞术，对中药复方癌宁诱导胃癌细胞凋亡机制进行研究。结果：顺铂、癌宁组与空白对照比较，TGF－β1、Fas和Fas-L基因表达产物含量显著增高（P＜0．01）。结论：癌宁对人胃癌细胞的诱导凋亡作用与其对抑癌基因及细胞因子表达的改变有关。 |
| 关 键 词： | 中药复方 癌宁 基因 细胞因子 胃癌 |
| 文章编号： | 1003-8507(2001) 01-0006-02 |
| 修稿时间： | 2000年6月6日 |
CHANGES OF GENES AND CELL FACTORS OF THE HUMAN GASTRIC CANCER CELL SGC-7901BY AINING |
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| SU Mian cheng,DAI Ping,LU Xiao ying,et al..CHANGES OF GENES AND CELL FACTORS OF THE HUMAN GASTRIC CANCER CELL SGC-7901BY AINING[J].Modern Preventive Medicine,2001,28(1):6-7. | |
| Authors: | SU Mian cheng DAI Ping LU Xiao ying |
| Institution: | SU Mian cheng,DAI Ping,LU Xiao ying,et al.National Engineering Research Center for Modernization of TCM,Zhuhai 519020. |
| Abstract: | Objective: To investigate the effects of Aining on the genes and cell factors of the human gastric cancer cells. Methods: Flow cytometry (FMC) was adopted to explore the inducing apoptosis mechanism of Aining. Rusults: Compared with the blank group, the expression of Fas 、 Fas-L genes as well as the cell factor TGF--β1 was high (P＜0. 01) in both the Aining group and the cisplatin (DDP) group. Conclusion: The mechanism ofinducing the human gastric cancer cells apoptosis by Aining had some relationship with the changes of genes and cell factors. |
| Keywords: | Traditional chinese medicine compounds Aining Gene Cell factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |