Maternal serum levels of VCAM-1, ICAM-1 and E-selectin in preeclampsia |
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Authors: | Kim Shin-Young Ryu Hyun-Mee Yang Jae Hyug Kim Moon-Young Ahn Hyun-Kyong Lim Ha-Jung Shin Joong-Sik Woo Hyuk-Jun Park So-Yeon Kim Young-Mi Kim Jin-Woo Cho Eun Hee |
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Institution: | Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
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Abstract: | Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. The aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) in sera of normal and preeclamptic pregnancies. We studied the serum levels of sVCAM-1, sICAM-1 and sE-selectin in normal pregnant women (n=63), mild preeclampsia (n=33) and severe preeclampsia (n=82). Concentrations of soluble adhesion molecules were determined with enzyme-linked immunoassay (ELISA). Serum concentrations of sVCAM-1 were significantly higher in both mild (p=0.004) and severe preeclampsia (p=0.000) than normal pregnancy. There were also significant differences in sVCAM- 1 levels between mild and severe preeclampsia (p=0.002). sICAM-1 levels of severe preeclampsia were statistically different from those of normal pregnancy (p=0.038). Levels of sE-selectin were elevated in both mild (p=0.011) and severe preeclampsia (p=0.000) compared to normal pregnancy, but no statistical difference between the mild and severe preeclampsia (p=0.345). These results suggest that all three soluble adhesion molecules are increased in severe preeclampsia, and sVCAM-1 among them may be useful in predicting the severity of preeclampsia. |
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Keywords: | Pre-Eclampsia Cell Adhesion Molecules Vasurlar Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1 E-Selectin |
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