Mechanism of mobilization of mesenchymal stem cell under the effect of granulocyte colony-stimulating factor |
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Authors: | V V Zhdanov L A Stavrova A M Dygai E D Goldberg |
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Institution: | (1) Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia |
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Abstract: | We studied the role of cell components and extracellular matrix of the microenvironment in the mechanisms of mobilization
of mesenchymal bone marrow stem cells under the effect of granulocyte colony-stimulating factor in vitro and in vivo on CBA/CaLac mice. It was found that the mechanisms underlying the dissociation effect of granulocyte colony-stimulating
factor do not include its direct effect on the interaction of precursor cells with fibronectin. The major role in this process
is played by changes in functional state of stromal precursors and cell component of the microenvironment induced by granulocytic
colony-stimulating factor and mediated by regulatory systems of the microorganism.
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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 169–172, July, 2007 |
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Keywords: | granulocyte colony-stimulating factor mobilization fibronectin mesenchymal stem cells |
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