心血管事件高危患者餐后高敏C反应蛋白浓度变化及氟伐他汀干预的影响

目的 研究心血管事件高危患者高脂餐后血浆高敏C-反应蛋白(hsCRP)浓度的变化,探讨极短期氟伐他汀对血浆hsCRP浓度的影响。方法 43例冠心病及其等危症患者随机分为氟伐他汀组(22例)和常规治疗组(21例),分别在常规治疗的基础上加服氟伐他汀(40 mg/d)和安慰剂。治疗前和1周后接受高脂餐负荷试验,检测空腹和餐后4 h血浆hsCRP和血脂水平。结果 两组患者的餐后血浆甘油三酯和hsCRP浓度较空腹水平明显升高(P<0.05)。1周后,常规治疗组的空腹和餐后血浆hsCRP浓度与血脂水平无显著变化;氟伐他汀组的餐后血浆甘油三酯和hsCRP浓度较治疗前显著降低,但血浆hsCRP浓度降低与血脂的变化无显著相关。结论 极短期氟伐他汀治疗有效降低心血管事件高危患者餐后升高的血浆hsCRP浓度。

Influence of fluvastatin on postprandial high-sensitivity C-reactive protein concentrations in patients at high risk of cardiovascular event

Objective To study the changes of postprandial plasma high-sensitivity C-reactive protein (hsCRP) concentrations after a high-fat meal (800 calorie; 50g fat) in patients at high risk of cardiovascular event, and explore the influence of fluvastatin on hsCRP concentration in very short time. Methods Forty-three patients at high risk of cardiovascular disease were randomly divided into two groups to accepteither fluvastatin (40 mg/d) (FLU group, n = 22) or placebo (ROU group, n =21) at the base of routine therapy. All patients received an oral high-fat meal at baseline and one week later. The concentrations of plasma triglyceride (TG) , total cholesterol, LDL-cholesterol, HDL-cholesterol and hsCRP in fasting state and at 4 hours postprandially were measured. Results The postprandial plasma TG and hsCRP concentrations increased significantly ( P < 0. 05) in all patients. After one week, the fasting or postprandial plasma lipids levels and hsCRP concentration did not significantly changed in ROU group comparing to the baseline, while the postprandial plasma TG and hsCRP concentrations significantly decreased in FLU group. The reduction of plasma hsCRP concentration was not significantly related to the changes of plasma lipids levels. Conclusion Fluvastatin effectively reduced postprandial plasma hsCRP concentrations in patients at high risk of cardiovascular event in very short time.