兔肩关节前向不稳实验模型的建立

目的:建立研究肩关节不稳的动物(兔)模型,为进行相关研究提供实验依据。方法:取6只骨骼成熟的雄性新西兰大白兔进行肩关节正常组织结构的解剖,研究手术入路。通过解剖兔的肩关节并测量其关节活动度,了解兔肩关节与人肩关节骨骼、周围肌肉组织及关节囊韧带组织的类似程度,建立兔肩关节不稳动物模型的手术入路及手术方法。另取18只兔分为2组,其中12只为实验组,均取右侧肩关节,手术切开肩胛下肌腱显露盂肱关节,并切除前下方盂缘及其相连的韧带组织,制作肩关节前方不稳模型,分别于术后6周及12周(各6只)取材;其余6只为对照组,仅切开皮肤及浅层肌肉组织,于术后12周取材。测量盂肱关节活动度及稳定性。结果:兔肩关节大体解剖与人类相类似,实验组兔关节前向稳定性明显差于对照组,所有实验组肩关节均有2度以上的前向不稳定存在。实验组兔肩关节后伸、内旋、外旋及外展活动明显受限,而对照组肩关节活动基本正常。结论:兔是建立肩关节不稳动物模型和进行相关实验研究的合适动物,本实验建立的兔肩关节前向不稳模型适用于盂肱关节前向不稳的研究。

Establishment of Anterior Instability of Gienohumeral Joint on Rabbits

Objective To establish the animal mode(lrabbit)of shoulder instability for providing the experimentalbasis of related studies. Methods shoulder joints of 6 skeletally matured New Zealand white rabbits were measuredwith the anatomical characteristics and joint motion range in order to determine the operative approach,thesimilarities of skeletal structure,surrounding muscles,joint capsule and ligaments between rabbit and human werecompared. Eighteen rabbits,weighing between 2.5 and 3kg were randomized into 2 ...