| 同型半胱氨酸与先天性心脏病 |
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| 引用本文： | 张静,王新. 同型半胱氨酸与先天性心脏病[J]. 中国妇幼健康研究, 2006, 17(6): 504-506 |
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| 作者姓名： | 张静 王新 |
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| 作者单位： | 中南大学湘雅二医院妇产科,湖南,长沙,410011 |
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| 摘 要： | 先天性心脏病是先天畸形中最常见的类型之一, 是一种多基因遗传病.近年来大量研究证据表明,血浆同型半胱氨酸水平升高与先天性心脏病的发生存在密切联系,同型半胱氨酸代谢异常是诱发胎儿出生缺陷的一个独立的危险因素.该文对有关同型半胱氨酸导致先天性心脏病的可能机制,代谢过程中某些关键酶及其基因多态性与先天性心脏病关系的研究进行综述.
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| 关 键 词： | 先天性心脏病 同型半胱氨酸 酶 基因多态性 |
| 文章编号： | 1673-5293（2006）06-0504-03 |
| 收稿时间： | 2006-09-27 |
| 修稿时间： | 2006-09-27 |
Homocysteine and congenital heart disease |
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| ZHANG Jing,WANG Xin. Homocysteine and congenital heart disease[J]. Chinese Journal of Maternal and Child Health Research, 2006, 17(6): 504-506 |
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| Authors: | ZHANG Jing WANG Xin |
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| Affiliation: | Department of Gynecology and Obstetrics , The Second Xiangya Hospital of Zhongnan University, Hunam Changsha 410011 ,China |
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| Abstract: | Congenital heart disease(CHD),a multi-gene disorder,is the most common type of congenital malformations.The large amount of evidences indicate that increased plasma homocysteine level is associated closely with development of CHD.Abnormality in homocysteine metabolism is an independent risk factor of birth defect.The article reviewed possible mechanisms that homocysteine induces CHD,relationship between genetic polymorphisms of key enzyme in metabolic process and CHD. |
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| Keywords: | congenital heart disease homocysteine enzyme genetic polymorphism |
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