自体骨髓单个核细胞移植治疗糖尿病性下肢缺血的临床观察

目的观察自体骨髓单个核细胞移植治疗糖尿病性下肢缺血的疗效。方法应用自体骨髓单个核细胞移植治疗20例22条糖尿病性下肢缺血。全部为2型糖尿病的下肢血管并发症。结果总的疼痛缓解率为85.0%,截肢3例(13.6%)。对缓解患者的冷、凉感觉,总有效率为100.0%。7例患者接受了下肢动脉造影显示有不同程度的新生侧支血管形成。踝部经皮氧分压测定显示绝大多数高于临床上截肢的最低临界值20mmHg(1mmHg=0.133kPa)。结论自体骨髓单个核细胞移植治疗糖尿病性下肢缺血是一种相对简单、安全、有效的方法。

Clinical study of autologous transplantation of bone-marrow mononuclear cells for treating patients with diabetic lower limb ischemia

Objective To investigate the efficiency of autologous transplantation of bone-marrow mononuclear cells for treatment of patients with diabetic lower limb ischemia. Methods Twenty patients of type 2 diabetes (22 legs) with diabetic lower limb ischemia were treated by autologous transplantation of bone-marrow mononuclear cells. Results All ischemic legs were preserved except three feet, which were amputated due to the previously existed foot gangrene in one and unsolved pain in two. The pain-alleviated rate was 85.0%. The amputation rate was 13.6%. The skin turned warm in all legs(100.0%). TcPO2 of the ischemic legs was elevated in 17 patients with 19 legs. Angiography showed a noticeable increase of visible collateral vessels in 7 patients with 8 limbs who had angiographic follow-up. Conclusion Autologous transplantation of bone-marrow mononuclear cells could be a simple, safe, and effective method to treat patients with diabetic lower limb ischemia.