| 载脂蛋白A-I 基因多态性与胆固醇合成逆转关系的研究进展 |
| |
| 引用本文： | 张翼,赵静,潘思源. 载脂蛋白A-I 基因多态性与胆固醇合成逆转关系的研究进展[J]. 世界科学技术-中医药现代化, 2014, 16(7): 1649-1654 |
| |
| 作者姓名： | 张翼 赵静 潘思源 |
| |
| 作者单位： | 北京中医药大学中药学院/中药基础与新药研究北京市重点实验室 北京 100102;北京中医药大学基础医学院 北京 100029;北京中医药大学中药学院/中药基础与新药研究北京市重点实验室 北京 100102 |
| |
| 基金项目： | 国家自然科学基金委面上项目（31071989）：用五味子素B 制造的急性、单纯性高甘油三酯血症实验动物模型分子靶标研究，负责人：潘思源。 |
| |
| 摘 要： | 载脂蛋白A-I（ApoA-I）是载脂蛋白A 家族中最早发现的蛋白，在脂质代谢过程中具有重要作用，主要参与胆固醇的合成及转运。ApoA-I 与高脂血症及动脉粥样硬化的发生息息相关，临床上已经将血浆ApoA-I/ApoB 作为高脂血症的指标之一。本文就ApoA-I 基因多态性及其对胆固醇合成逆转（RCT）关系的研究进展进行综述。
|
| 关 键 词： | 载脂蛋白A-I 基因多态性 高脂血症 胆固醇逆向转运 |
| 收稿时间： | 2013-11-13 |
| 修稿时间： | 2014-01-09 |
Study Progress in Apolipoprotein A-I's Gene Polymorphism and Its Relationship with Reverse Cholesterol Transport |
| |
| Zhang Yi,Zhao Jing and Pan Siyuan. Study Progress in Apolipoprotein A-I's Gene Polymorphism and Its Relationship with Reverse Cholesterol Transport[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2014, 16(7): 1649-1654 |
| |
| Authors: | Zhang Yi Zhao Jing Pan Siyuan |
| |
| Affiliation: | School of Chinese Materia Medica, Beijing University of Chinese Medicine / Beijing Key Laboratory for Basic Chinese Materia Medica and New Drug Research, Beijing 100102, China;School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine / Beijing Key Laboratory for Basic Chinese Materia Medica and New Drug Research, Beijing 100102, China |
| |
| Abstract: | Apolipoprotein A-I (apoA-I) is a member of the apolipoprotein A family, which was discovered the earliest. It has an important role in the regulation of lipid metabolism, which mainly includes cholesterol synthesis and transfer. Therefore, apoA-I is closely related to hyperlipidemia and atherosclerosis. Clinically, serum ApoA-I/ApoB has been used as one of the indexes of hyperlipidemia. This article reviewed the study progress in ApoA-I's gene polymorphism and its relationship with reverse cholesterol transport (RCT). |
| |
| Keywords: | Apolipoprotein A-I gene polymorphism hyperlipidemia reverse cholesterol transport |
|
| 点击此处可从《世界科学技术-中医药现代化》浏览原始摘要信息 |
|
点击此处可从《世界科学技术-中医药现代化》下载全文 |
