心脑血脉宁减少家兔易损斑块模型斑块内血肿、稳定斑块的研究*

笔者应用新加黄龙汤保留灌肠辅助治疗急腹症术后患者,临床疗效显著。1临床资料40例均为2007—2009年间本院住院的急腹症手术患者,其中急性胆囊炎、胆囊结石行胆囊切除术后12例,急性化脓性阑尾炎行阑尾切除术后19例,急性肠梗阻术后6例;

Effect of Xinnao Xuemaining on reducing plaque hematoma and stable plaques of vulnerable plaque in rabbits with atherosclerosis

Objective] To observe the effects of Xinnao Xuemaining on reducing plaque hematoma and the expression of PDGFR of vulnerable plaque in rabbits with atherosclerosis.Methods] The vulnerable atherosclerotic plaque model was reproduced by operation on abdominal aorta endothelium for inducing sacculus pull injury with the foraging with high cholesterol lipid feeding.Ribbits were divided into three groups:model group,sham operation group and Xinnao Xuemaining group.The experiment lasted for 15 weeks.After killing at the end of experiment,the sample of abdominal aorta was collected for HE staining and microscopic lesion examination,counting of the number of plaque hematoma and detecting the protein content of PDGFR by immunohistochemistry.Results] HE observation was found 6 rabbits of the 12 plaque hematoma in model group,and three rabbits,three plaque hematoma in Xinnao Xuemaining group.The new blood vessels lacked pericytes surrounded,and after the intervention of Xinnao Xuemaining,pericytes surrounded the new blood vessels increased.The results of immunohistochemical staining showed that the expression of platelet derived growth factor receptor in Xinnao Xuemaining group enhanced significantly compared with model group (P<0.01).Conclusion] Xinnao Xuemaining can reduce plaque hematoma of vulnerable plaque in rabbits with atherosclerosis and promote plaque neovascularization mature,whose mechanism may be related to increased expression of PDGFR and raised on pericytes.