尿毒清灌肠治疗尿毒症性皮肤瘙痒的疗效观察

目的:探讨尿毒清颗粒灌肠对尿毒症性皮肤瘙痒的临床疗效。方法: 将83例患者随机分为对照组21例和爱西特组30例以及尿毒清组32例，对照组选择常规血液透析（每周3次），爱西特组、尿毒清组分别在常规透析基础上应用爱西特或尿毒清灌肠。观察三组治疗前后皮肤瘙痒状况、透析前尿素氮(BUN)、血肌酐(Cr)、血尿酸(UA)、血红蛋白(Hb)、超敏C反应蛋白（hs-CRP）血钙（Ca）、血磷（P）、甲状旁腺激素（PTH）的变化。结果：尿毒清组及爱西特组均能改善皮肤瘙痒，但尿毒清组改善更明显(P < 0. 05)；尿毒清组和爱西特组治疗后透析前BUN、Cr、UA、hs-CRP、P、Ca、PTH与治疗前相比均明显改善(P < 0. 05)；但尿毒清组与爱西特组比较，尿毒清组hs-CRP、PTH、Hb改善更加明显(P < 0. 05)。结论：尿毒清灌肠可以改善尿毒症微炎症状态，对皮肤瘙痒有明显的疗效。

The clinical study of Uremia Clearance Granules-enema on uraemic itching

Objective: To investigate the clinical efficacy of Uremia Clearance Granules-enema on uraemic itching. Methods: 83 patients were randomly divided into control group with 21 cases, activated carbon –enema group with 30 cases and Uremia Clearance Granules-enema group with 32 cases.All groups were treated with hemodialysis（3 times per week）. Activated carbon-enema group and Uremia Clearance Granules-enema were either treated with additional enema. The uraemic itching was analyzed pre- or post-treatment,and BUN、Cr、UA、Hb、hs-CRP、Ca、P and PTH were detected respectively in the three groups. Results: Both enema groups have significantly effect on uraemic itching compared with the control group（P <0.05）. However, uraemic itching was alleviated much better in the Uremia Clearance Granules-enema group (P < 0. 05). The BUN 、Cr、UA、hs-CRP、Ca、P and PTH were significantly improved in both enema groups(P < 0. 05). However, in comparing with Activated carbon-enema group, hs-CRP、PTH and Hb were improved more better(P < 0. 05). Conclusion: Uremia Clearance Granules-enema can effectively relieve uraemic itching and reduce the microinflammation state in hemodialysis patients.