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| 心房颤动与白介素-6-174G/C、-572C/G、-597G/A位点基因多态性的关系 | |
| 引用本文： | 郑金国,高淑萍,葛利军,邓新桃,何永辉,石桂良,潘闽.心房颤动与白介素-6-174G/C、-572C/G、-597G/A位点基因多态性的关系[J].天津医药,2011,39(1):4-6. |
| 作者姓名： | 郑金国 高淑萍 葛利军 邓新桃 何永辉 石桂良 潘闽 |
| 作者单位： | 1. 江苏省兴化市人民医院心内科ICU,225000 2. 宁夏自治区人民医院心内科 3. 南通大学附属医院心内科 |
| 基金项目： | 宁夏自然科学基金资助项目，南通市社会发展项目 |
| 摘 要： | 目的:探讨江苏南通地区汉族人群中白细胞介素(IL)-6-174G/C(rs1800795)、-572C/G(rs1800796)、-597G/A(rs1800797)单核苷酸多态性(SNP)与血清IL-6水平以及房颤发病之间的关系。方法:分别测定房颤组和对照组血清IL-6及其他临床指标,测量左心房长径(LAD);提取基因组DNA,聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术扩增目的基因片段并酶切。结果:房颤组IL-6和LAD与对照组比较差异有统计学意义(P﹤0.01);房颤组IL-6-572C/G基因型分布G/C+G/G明显高于对照组(P﹤0.05),且房颤组G等位基因频率明显大于对照组(P﹤0.01),IL-6-174G/C位点C等位基因突变率极低,IL-6-597G/A未见A等位基因突变。结论:IL-6-572C/G位点G等位基因突变导致了机体血清IL-6水平升高,可能与房颤的发病有关。 |
| 关 键 词： | atrial fibrillation inflammation interleukin-6 polymorphism.single nucleotiide polymorphism.restriction fragment length lipids 脂类 |
Relationship between Atrial Fibrillation and the IL-6-174G/C,-572C/G and -597G/A Polymorphism |
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| ZHENG Jinguo,GAO Shuping,GE Lijun,DENG Xintao,HE Yonghui,SHI Guiliang,PAN Min.Relationship between Atrial Fibrillation and the IL-6-174G/C,-572C/G and -597G/A Polymorphism[J].Tianjin Medical Journal,2011,39(1):4-6. | |
| Authors: | ZHENG Jinguo GAO Shuping GE Lijun DENG Xintao HE Yonghui SHI Guiliang PAN Min |
| Institution: | Department of Cardiology, People’s Hospital of Xinghua City, Jiangsu 225700,China |
| Abstract: | Objective: To explore the relationships among atrial fibrillation (AF), interleukin-6 (IL-6) and single nucleotide polymorphisms (SNP) of the IL-6-174G/C, -572C/G and -597G/A. Methods: The serum levels of IL-6, lipid and other clinical indicators were measured. The left atrial diameter (LAD) was measured by echocardiography (UCG). The frequency distributions of genotypes and alleles of the IL-6-174G/C, -572G/C and -597G/A were amplified by polymerase chain reaction-restriction fragment length polymorphism (... |
| Keywords: | atrial fibrillation inflammation interleukin-6 polymorphism single nucleotide polymorphism restriction fragment length lipids |
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