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| 益气养荣方对化疗所致骨髓抑制小鼠的影响 | |
| 引用本文： | 王振强,陈宝义,李小江,杨文英,谢丽娜. 益气养荣方对化疗所致骨髓抑制小鼠的影响[J]. 天津中医药, 2011, 28(1): 56-58 |
| 作者姓名： | 王振强 陈宝义 李小江 杨文英 谢丽娜 |
| 作者单位： | 1. 河北省泊头市中医医院肿瘤科,泊头,062150 2. 河北省泊头市卫生学校,泊头,062150 3. 天津中医药大学第一附属医院,天津,300193 4. 河北省徐水县人民医院,徐水,072550 |
| 基金项目： | 河北省中医药管理局指令项目 |
| 摘 要： | [目的]观察益气养荣方对化疗所致骨髓抑制小鼠的影响。[方法]将30只Wistar大鼠随机分为空白组、对照组、中药组,每组10只。空白组予腹腔注射生理盐水,剂量为150 mg/kg;后两组均腹腔注射环磷酰胺150 mg/kg复制小鼠骨髓抑制模型,1 d后全部经目内眦眼底取血,检测血常规。中药组予益气养荣方10 mL/kg灌胃,2次/d,连续10 d。检测血常规、粒细胞-巨噬细胞集落刺激因子含量和脾脏指数。[结果]中药组体质量显著高于对照组,并且中药组外周血白细胞及血小板较对照组显著升高,中药组脾脏指数较实验组显著升高。[结论]益气养方汤可以控制大鼠体质量的下降,明显升高放化疗后骨髓抑制所致的外周血白细胞及血小板的减少,同时控制脾脏的增大。 |
| 关 键 词： | 益气养荣方 化疗 骨髓抑制 |
| 收稿时间： | 2010-08-20 |
Influence of Yiqi Yangrong decoction on mice with bone marrow depression induced by chemotherapy |
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| WANG Zhen-qiang,CHEN Bao-yi,LI Xiao-jiang. Influence of Yiqi Yangrong decoction on mice with bone marrow depression induced by chemotherapy[J]. Tianjin Journal of Traditional Chin Medicine, 2011, 28(1): 56-58 | |
| Authors: | WANG Zhen-qiang CHEN Bao-yi LI Xiao-jiang |
| Affiliation: | WANG Zhen-qiang1,CHEN Bao-yi2,LI Xiao-jiang3,et al(1.Botou TCM Hospital,Botou 062150,China,2.Hebei Botu Health School,3.The First Affiliated Hospital of Tianjin University of TCM,Tianjin 300193,China) |
| Abstract: | [Objective] To observe the effect of Yiqi Yangrong decoction on mice with bone marrow depression induced by chemotherapy.[Methods] Thirty Wistar rats were randomly divided into blank group,control group,TCM group and each group composed of 10 rats.The rats of blank group was treated by intraperitoneal injection of physiological saline,150 mg/kg.After intraperitoneal injection of cyclophosphamide,150 mg/kg,the rats of both groups were suffered from bone marrow inhibition.One day after blood sample was obtain... |
| Keywords: | Yiqi Yangrong decoction chemotherapy Bone marrow depression |
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