| Bcl-2和增殖细胞核抗原在绝经后子宫肌瘤中的表达及意义 |
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| 引用本文： | 陈红漫,薛凤霞. Bcl-2和增殖细胞核抗原在绝经后子宫肌瘤中的表达及意义[J]. 天津医药, 2011, 39(1): 14-16 |
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| 作者姓名： | 陈红漫 薛凤霞 |
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| 作者单位： | 1. 天津第五中心医院妇产科2. 天津医科大学总医院 |
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| 摘 要： | 目的:探讨Bcl-2及增殖细胞核抗原(PCNA)对绝经后子宫肌瘤发病的影响因素,为绝经后非萎缩肌瘤的病因学研究提供一定依据。方法:应用免疫组化SP法检测117例绝经前后子宫肌瘤及其相应肌壁中Bcl-2和PCNA的表达情况。结果:(1)绝经前肌瘤组Bcl-2的阳性表达率高于绝经后肌瘤组(P<0.05);绝经前分泌期肌瘤组高于增生期肌瘤组,绝经后非萎缩肌瘤高于绝经后萎缩肌瘤(P<0.05)。(2)绝经前增生期肌瘤组及分泌期肌瘤组、绝经后非萎缩肌瘤组Bcl-2表达强度高于其相应肌壁(P<0.05);绝经后萎缩性肌瘤组Bcl-2的表达强度与其相应肌壁差异无统计学意义(P>0.05)。(3)绝经前肌瘤组PCNA阳性表达率高于绝经后肌瘤组(P<0.05);绝经后非萎缩肌瘤高于绝经后萎缩性肌瘤组(P<0.05)。(4)绝经前增生期肌瘤组及分泌期肌瘤、绝经后非萎缩肌瘤组PCNA表达强度均高于其相应肌壁(P<0.05);绝经后萎缩性肌瘤组PCNA表达强度与其相应肌壁差异无统计学意义(P>0.05)。结论:绝经后非萎缩肌瘤同萎缩性肌瘤具有不同的临床病理特征,与凋亡失调及细胞异常增殖有关。
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| 关 键 词： | 平滑肌瘤 子宫肿瘤 绝经期 基因 bcl-2 增殖细胞核抗原 免疫组织化学 |
| 收稿时间： | 2010-03-17 |
| 修稿时间： | 2010-09-09 |
Expression and Significance of Bcl-2 and Proliferating Cell Nuclear Antigen in Postmenopausal Leiomyoma |
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| CHEN Hongman,XUE Fengxia. Expression and Significance of Bcl-2 and Proliferating Cell Nuclear Antigen in Postmenopausal Leiomyoma[J]. Tianjin Medical Journal, 2011, 39(1): 14-16 |
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| Authors: | CHEN Hongman XUE Fengxia |
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| Affiliation: | CHEN Hongman,XUE Fengxia Department of Obstetrics and Gynecology,The Fifth Central Hospital of Tianjin,Tianjin 300450,China |
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| Abstract: | Objective:To investigate the expression of Bcl-2 and proliferating cell nuclear antigen (PCNA) in postmenopausal leiomyoma. Methods:The expressions of Bcl-2 and PCNA were examined by immunohistochemical technique in 117 postmenopausal patients with leiomyoma. Results:(1)The positive expression rate of Bcl-2 was significantly lower in premenopausal leiomyoma group than that of postmenopausal leiomyoma group (P < 0.05).(2)The expression level of Bcl-2 was significantly higher in proliferative and secretory ph... |
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| Keywords: | leiomyoma uteruine neoplasms menopause genes Bcl-2 proliferating cell nuclear antigen immunohistochemistry |
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