血清CA125、HE4联合阴道彩色多普勒在卵巢癌高危人群早期筛查中的临床价值

目的 探讨血清癌胚抗原125(CA125)、人附睾蛋白4(HE4)联合阴道彩色多普勒检查在卵巢癌高危人群早期筛查中的临床价值.方法 将纳入研究的对象分为3组:健康组100例,高危组80例,卵巢癌组32例.对比3组血清CA125、HE4水平及超声评分.结果 卵巢癌组HE4和CA125水平及超声评分较其他两组明显升高,差异有统计学意义(P＜0.01);高危组的阳性检出率及CA125水平均高于健康组,差异均有统计学意义(P＜0.05);高危组中,CA125、HE4联合超声的阳性检出率均高于其他检测方法(P＜0.05);CA125+HE4联合阴道超声筛查的敏感性及特异性明显高于其他筛查方法,差异有统计学意义(P＜0.05);HE4特异性明显高于CA125,但敏感性低于CA125(P＜0.05).结论 CA125、HE4联合阴道超声检查有利于提高卵巢癌高危人群的早期筛查,便于节约医疗成本,提高检出率.

Clinical value of serum CA125 and HE4 combined with vaginal color Doppler in early screening of ovarian cancer among high-risk populations

Objective To explore the clinical value of serum CA125 and HE4 combined with transvaginal color Doppler(TVCD)examination in early screening of ovarian cancer among high-risk populations.Methods The included research subjects were divided into 3 groups:100 cases in the healthy group,80 cases in the high-risk group and 32 cases in the ovarian cancer group.The serum CA125 and HE4 levels and ultrasonic scores were compared among 3 groups.Results The HE4 and CA125 levels and ultrasound scores in the ovarian cancer group were significantly increased compared with the other two groups,the difference was statistically significant(P＜0.01);the positive detection rate of CA125 plus HE4 levels combined with ultrasonic examination in the high-risk group was higher than that of other detection method(P＜0.05);the sensitivity and specificity of CA125+HE4 combined with vaginal ultrasound screening were obviously higher than those of other screening method,the difference was statistically significant(P＜0.05);the specificity of HE4 was significantly higher than that of CA125,but its sensitivity was lower than that of CA125(P＜0.05).Conclusion CA125 and HE4 combined with TVCD is helpful for early screening of ovarian cancer in high-risk populations,easy to save medical cost and improves its detection rate.