丁苯酞对脑梗死认知障碍患者记忆运动及事件相关电位的影响

目的 探讨丁苯酞对脑梗死认知障碍患者记忆、运动及事件相关电位(ERP)的影响.方法 选取134例脑梗死认知障碍患者为受试对象,随机数字表法分为研究组和对照组,各67例.对照组予以常规脑梗死治疗及认知改善干预措施,研究组在上述基础上予以丁苯酞口服方案,持续治疗30 d后观察疗效.对比两组患者治疗前后认知功能评分、记忆力评分、运动功能评分、ERP检查结果和不良反应.结果 治疗30 d后,两组蒙特利尔认知评估量表(MoCA)评分(27.2±4.9)分 vs.(25.1±4.1)分]、记忆力与回忆力评分总和(5.5±0.5)分 vs.(4.9±0.5)分]、运动功能评定量表评分(85.6±6.2)分 vs.(74.2±6.1)分]、P3波幅(9.5±0.9)μV vs.(8.1±0.9)μV]均较治疗前明显提升,在上述评估结果中,研究组均大于对照组(P<0.05);N1、N2、P2、P3潜伏期检测结果则均较治疗前明显降低(P<0.05),研究组P2、P3潜伏期检测结果均小于对照组(P<0.05).治疗后,两组患者均无严重不良反应发生.结论 在常规脑梗死治疗干预基础上予以丁苯酞口服用药方案能有效提高治疗效果.

The influence of butylphthalide on the memory,movement and ERP in patients with cerebral infarction cognitive impairment

Objective To investigate the effect of butylphthalide on the memory,movement and ERP (event-related potentials) in patients with cerebral infarction cognitive impairment.Methods A total of 134 patients with cerebral infarction cognitive impairment were randomly divided into treatment group (67 patients) and control group (67 patients).All patients were given conventional cerebral infarction treatment as well as cognitive improvement intervention.Oral administration of butylphthalide was added onto the patients in the treatment group.Curative effects were observed after 30 days′ continued treatment.The cognitive function scores,memory scores,movement scores,ERP test and adverse reaction were compared between the two groups before and after treatment.Results After 30 days′ treatment,two groups of the montreal cognitive assessment scale (MoCA) scores were 27.2±4.9 and 25.1±4.1 respectively;the total scores of memory were 5.5±0.5 and 4.9±0.5 respectively;the scores of motor assessment scale (Fugl-meyer) were 85.6±6.2 and 74.2±6.1 respectively and P3 amplitudes were (9.5±0.9)μV and (8.1±0.9)μV respectively.All the indexes mentioned above in treatment group were significantly increased compared with those of before treatment(P<0.05).The results of N1,N2,P2 and P3 in the latency detection were significantly decreased compared with those of before treatment(P<0.05).And the results of P2 and P3 in the latency detection of the treatment group were shorter than those of the control group(P<0.05).After treatment,no adverse reaction was observed in both groups.Conclusion Based on conventional cerebral infraction treatment,oral administration of butyraldehyde effectively improve the therapeutic effect.