不同聚乙二醇4000散服用方案对肠道清洁度的影响及安全性评价研究

目的 探讨不同聚乙二醇4000散口服方案对肠道清洁度的影响及安全性.方法 选取2015年4-10月在该院胃肠镜中心行无痛结肠镜检查的患者280例,分为A组(90例)、B组(94例)、C组(96例).3组采用不同方案服用聚乙二醇溶液,比较3组肠腔清洁度情况、前晚睡眠情况、大便次数及不良反应.结果 A组肠道清洁度和睡眠质量较B组高(P＜0.05),与C组比较差异无统计学意义(P＞0.05).A组腹胀(腹痛)、恶心(呕吐)发生率较C组低(P＜0.05),B组大便次数较另外两组明显增多(P＜0.05).结论 1L+3L的聚乙二醇服用方案的肠道清洁有效率高,不良反应小,特别适用于睡眠质量差、体质差及便秘严重的患者.

The quality of cleanliness and safety on the bowel preparation with different program of oral polyethylene glycol 4000

Objective To investigate the effect and safety of different polyethylene glycol 4000 (PEG)oral regimen on cleanliness of bowel preparation.Methods 280 patients received painness colonoscopy examination were randomly divided into A,B and C groups:group A which drank 1 L of PEG solution the day before colonoscopy and the rest 3 L in the morning at the day of colonoscopy;group B drank 2 L of PEG solution the day before colonoscopy and the rest 2 L in the morning at the day of colonoscopy;group C drank 4 L of PEG solution in the morning at the day of colonoscopy.Bowel cleanliness after taking the drug,stool frequency and adverse events before colonoscopy were observed.Results Group A had better bowel preparation compare with group B (P＜0.05),which was similar to that of group C(P＞0.05);But group A had lower incidence of abdominal distension(abdominal pain),nausea(vomiting) than group C(P＜0.05);and group B had worse sleep quality and more defecate frequency than the other two groups(P＜0.05).Conclusion Drink 1 L of PEG solution the day before colonoscopy and the rest 3 L in the morning at the day of colonoscopy provided a better quality preparation and with less adverse reaction,especially suitable for patients with poor quality of sleep,poor health and severe constipation.