Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A-C: Fibronectin Expression Regulators from Aspergillus novofumigatus |
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Authors: | Ishikawa Kazuki Hosoe Tomoo Itabashi Takeshi Sato Fumiaki Wachi Hiroshi Nagase Hiromasa Yaguchi Takashi Kawai Ken-Ichi |
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Institution: | Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. |
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Abstract: | Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells. |
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Keywords: | Aspergillus novofumigatus Novobenzomalvin Quinazolinobenzodiazepine Fibronectin expression regulator Alkaloids X-ray crystallography |
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