On the use of lesions of afferents to localize neurotransmitter receptor sites in the striatum |
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| Authors: | T. Hattori H.C. Fibiger |
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| Affiliation: | 1. Department of Anatomy, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada;2. Division of Neurological Sciences, University of British Columbia, Vancouber, B.C. V6T 1W5 Canada |
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| Abstract: | Rats received lesions of either the cortico-striatal or the nigrostriatal projections. Two to three days after either type of lesion, evidence for degenerating dendritic spines that were postsynaptic to degenerating striatal boutons was often encountered. This type of transsynaptic degeneration of spines indicates that it is inappropriate to conclude that decreases in the number of neurotransmitter receptors after these types of lesions necessarily indicates that these receptors are located presynaptically on striatal afferents. |
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| Keywords: | receptors striatum dopamine degeneration brain lesions 6-hydroxydopamine |
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