| 新型噁唑烷酮类抗菌药物的研究进展 |
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| 引用本文： | 翟鑫,汪玉梅,宫平. 新型噁唑烷酮类抗菌药物的研究进展[J]. 沈阳药科大学学报, 2006, 23(11): 739-744 |
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| 作者姓名： | 翟鑫 汪玉梅 宫平 |
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| 作者单位： | 1. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016
2. 石药集团,中奇制药技术(石家庄)有限公司,河北,石家庄,050000 |
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| 摘 要： | 目的阐述唑烷酮类抗菌药物的最新研究进展。方法根据近期关于新的唑烷酮类抗菌药物研究开发现状的29篇相关文献,对唑烷酮的3位芳基和5位侧链的结构改造特点进行整理和归纳。结果与结论大多数化合物具有提高的抗G+菌活性,部分化合物显示出抗G-菌的活性。另外,还介绍了一类具有扩大的抗菌谱的唑烷酮与其他类型抗菌药物形成的拼合化合物。
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| 关 键 词： | 唑烷酮类化合物 抗菌药物 构效关系 |
| 收稿时间： | 2006-03-21 |
Recent progress in the research of novel oxazolidinone antibacterial agents |
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| ZHAI Xin,WANG Yu-mei,GONG Ping. Recent progress in the research of novel oxazolidinone antibacterial agents[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(11): 739-744 |
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| Authors: | ZHAI Xin WANG Yu-mei GONG Ping |
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| Affiliation: | 1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical Uuniversity, Shenyang 110016, China ; 2. Zhongqi Pharmaceutical Technology ( SJZ |
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| Abstract: | Objective To review the recent developments in the research of oxazolidinone antibacterial drugs.Methods The structure modifications on 3-aryl groups and the side-chains of the oxazolidinone ring were summarized on the basis of published literature for oxazolidinones.Results and Conclusions Most compounds could improve antibacterial activities against G~ bacteria and some of them exhibited the activities against G~-bacteria.A series of oxazolidinone derivatives that hybridized with other classes of antibiotics,which showed the broad-spectrum antibacterial activities,were reviewed in the paper. |
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| Keywords: | oxazolidinones antibacterials structure-activity relationships(SAR) |
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