首页 | 本学科首页   官方微博 | 高级检索  
     


Relapse into mania or depression following lithium discontinuation: a 7-year follow-up
Authors:Cavanagh J  Smyth R  Goodwin G M
Affiliation:University of Glasgow Department of Psychological Medicine, Academic Centre, Gartnavel Royal Hospital, Glasgow, UK. jc199d@clinmed.gla.ac.uk
Abstract:OBJECTIVE: We aimed to assess whether outcome followed a worse course after acute lithium withdrawal. METHOD: Data were acquired by review of the clinical records on 14 cases and 28 controls matched for age, gender and time on lithium for about 7 years following discontinuation. RESULTS: Significant differences were found between cases and controls. Cases experienced more episodes of depression and total affective relapse. The log-rank test revealed a significantly lower survival probability in cases than controls (P < 0.0009). However, the increased risk of recurrence was largely confined to the interval immediately after lithium discontinuation. CONCLUSION: These results confirm that acute discontinuation of lithium leads to a high immediate relapse rate. Most of the excess morbidity over 7 years appears to be attributable to the first episode following discontinuation. Outcome was not worsened by discontinuation.
Keywords:relapse  mania  depression  lithium
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号