| 维生素E对大鼠肝、肾和脑组织过氧化脂质含量及谷胱甘肽过氧化物酶活性的影响 |
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| 引用本文： | 宋祥福,冯彪,石贵山,王柏. 维生素E对大鼠肝、肾和脑组织过氧化脂质含量及谷胱甘肽过氧化物酶活性的影响[J]. 吉林大学学报(医学版), 1996, 0(3) |
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| 作者姓名： | 宋祥福 冯彪 石贵山 王柏 |
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| 作者单位： | 白求恩医科大学实验动物部 |
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| 摘 要： | 本文探讨了维生素Ｅ（Ｖ＿Ｅ）对大鼠肝、肾和脑组织中过氧化脂质（ＬＰＯ）及谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性的影响。结果表明，５．０×１０￣（－５），１．０×１０￣（－４），２．０×１０￣（－４），４．０×１０（－４），６．０×１０￣（－５）Ｖ＿Ｅ，各剂量组大鼠肝、肾中ＬＰＯ含量均低于对照组，而脑组织中仅２．０×１０￣（－４）和６．０×１０￣（－４）组与对照组间有差异。ＧＳＨ－Ｐｘ活性只有２．０×１０￣（－４）和４．０×１０￣（－４）组与相应对照组有差异。结果提示：Ｖ＿Ｅ有降低ＬＰＯ的作用，但Ｖ＿Ｅ所致的ＧＳＨ－Ｐｘ活性升高与ＬＰＯ降低有一致性的原因有待进一步研究。
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| 关 键 词： | 维生素E，过氧化脂质，谷胱甘肽过氧化物酶 |
Effect of vitamin E on the content of lipideperoxygen and the activity of glutathione peroxidase in liver,kidney and brain of rats |
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| Song Xiangfu,Feng Biao,Wang Bai,et al. Effect of vitamin E on the content of lipideperoxygen and the activity of glutathione peroxidase in liver,kidney and brain of rats[J]. Journal of Jilin University: Med Ed, 1996, 0(3) |
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| Authors: | Song Xiangfu Feng Biao Wang Bai et al |
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| Affiliation: | The School of Preventive Medicine;The First Clinical College |
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| Abstract: | This report investigated the effect of vitamin E(VE)on the content of lipideperox-ygen (LPO) and the activity of glutathione peroxidase (GSH-Px)in the liver,kidney and brain ofrats.The result Showed that LPO contents of the different VE groups(5.0×10(-5),1.0×10(-4),2.0×10‘(-4),4.0×10(-4),6.0×10(-4))were all lower than those of control group in the liver and kidney ofrats,However there was difference only between 2.0×10(-4) and 6.0×10(-4) groups and control groupin the brain of rats. It indicated that VE might decrease LPO. But the reason that there was less uni-fomity between the activitv increase of GSH-Px and the content decrease of LPO needs to be stud-ied in the futre |
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| Keywords: | vitamin E lipideperoxygen glutathione peroxidase |
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