| 黑菇多糖对人白血病细胞系U_937的增殖及分化的实验研究 |
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| 引用本文： | 季明春,居中华.黑菇多糖对人白血病细胞系U_937的增殖及分化的实验研究[J].现代免疫学,1994,14(2):71-75. |
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| 作者姓名： | 季明春 居中华 |
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| 作者单位： | 扬州大学医学院微生物学教研室 |
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| 摘 要： | 用黑菇多糖体外处理人单核细胞性白血病细胞分化模型Ｕ９３７细胞，结果表明黑菇多糖明显抑制Ｕ９３７细胞体外增殖（ＩＣ５０２８０μｇ／ｍｌ）并诱导细胞向终末方向分化。经黑菇多糖诱导后的Ｕ９３７细胞，细胞形态发生显著变化，细胞膜标志和生化特征趋向成熟。
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| 关 键 词： | 黑菇多糖，U_（937）细胞，诱导分化 |
THE EFFECT OF PLEUROTUS SAPIDUS POLYSACCHARIDE (PPS) ON THE INHIBITION OF PROLIFERATION AND INDUCTION OF DIFFERENTION IN HUMAN LEUKEMIC MONOBLAST U937 CELL LINE |
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| Ji Mingchun,Ju Zhonghua,Tong Kun.THE EFFECT OF PLEUROTUS SAPIDUS POLYSACCHARIDE (PPS) ON THE INHIBITION OF PROLIFERATION AND INDUCTION OF DIFFERENTION IN HUMAN LEUKEMIC MONOBLAST U937 CELL LINE[J].Current Immunology,1994,14(2):71-75. |
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| Authors: | Ji Mingchun Ju Zhonghua Tong Kun |
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| Institution: | Ji Mingchun;Ju Zhonghua;Tong Kun(Yangzhou Medical College(Yang zhou 225001)) |
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| Abstract: | This investigation demonstrated that Pleurotus sapidus Polysaccharide(PPS)could inhibit the proliferation (IO50=280ug/ml) and induce terminal differentiation of U937 cell in vitro. After 3 days of incubation in medium containing 250μg/ml PPS,the U937 cells showed remarkable morphological changes,over 53% of the cells showed the ability to reduce non-specific esterase activity(ANAE positive),73.5% and59.5% of the cells expressed FcR and C3R respectively. PPS could also increase the activity of low density lipoprotein receptors on U937 cell surface. However, too high concentration of PPS could decreased ANAE and 125I-LDL binding activity. |
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| Keywords: | Pleurotus sapidus polysaccharide U937 cell Induction of differentiation |
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